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KMID : 0377619940590080621
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Korean Jungang Medical Journal
1994 Volume.59 No. 8 p.621 ~ p.626
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Effect of D-Penicillamine and Sodium EDTA on the Lead Content in the Urine
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Abstract
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Lead acetate solution (Pb2mg/ml) was intraperitoneally injected to male rats with Average body weight of 200 g, and the contents of -lead in the urine collected for every 24 hours _were determined. D -penicillamine (l0mg/3ml) and sodium-EDTA (20mg/3ml) as detoxicants were orally administered every 24 hours after lead acetate administration.
Lead contents in the urine were measured using dithizone method to extract lead and UV-spectrophotometry. Lead contents in the urine were significantly increased by both detoxicants, and this indicates that the two detoxicants exihibit significant detoxicating effects of lead poisoning. Sodium-EDTA as a lead detoxicant was superior to D-penicillamine a:id the detoxicating effect of them was the highest after 5 days of detoxicant administration.
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